CTCB - Members

 
 

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The Members Reflect the Interdisciplinary Nature of the CTCB

 

Malcolm Walkinshaw (Director of CTCB), SBS

 

  1. Protein-Ligand Interactions.

  2. Protein Structures of Medical Targets.

  3. Metal-Binding and Redox Proteins.

  

Robin Allshire, SBS

 

  1. How the centromere specific H3 variant CENP-A is delivered to and assembled into centromeric chromatin.

  2. Investigating the relationship between centromeric heterochromatin, CENP-A and kinetochore assembly.

 

Paul Barlow, SOC

 

  1. NMR spectroscopy applied to protein structure determination.

  2. Relating structure to function in the complement system.

  3. Atomic resolution structures and disease mechanisms.

 

Adrian Bird, SBS

 

  1. DNA methylation in health and disease.

  2. Specific interest in the neurological disorder Rett Syndrome which is caused by deficiency of a methylated DNA binding protein.

 

Mark Bradley, SOC

 

  1. Interfacing microarray technologies with combinatorial chemistry in the area of chemical biology. Metal-Binding and Redox Proteins.

  2. Development of cellular delivery and labelling techniques for the introduction of protein, small molecules and nucleic acids into cells.  

 

Peter Ghazal, CMVM

 

  1. Pathway Biology of Infection and Immunity - host-pathogen interactions in immune cells and modelling of molecular pathways in health and disease.

  2. Novel immunomodulators: proteins from parasites which divert host immunity.

  3. Biochip Medicine in Systemic response to disease ¡V develop biochip techniques/platforms for translating genomic/pathway research into clinical healthcare.

 

Andrew Millar, SBS

 

  1. Systems Biology approaches to study oscillating gene circuits include measuring kinetic parameters for the clock proteins with CTCB colleagues.

 

David Porteous, CMVM

 

  1. Molecular genetics and biology of schizophrenia and mood disorders.

  2. The structure and function of the DISC1 protein complex.

 

Graeme Reid, SBS

 

Jonathan Seckl, CMVM

 

  1. The role of 11beta-hydroxysteroid dehydrogenase type 1 as a cause of and therapeutic target for the Metabolic Syndrome and age-related cognitive disorders.

  2. Glucocorticoids and developmental 'programming' of adult cardiometabolic and CNS disorders.


Stephen Anderton, SBS

 

Douglas Armstrong, SOI

 

  1. Application of techniques from informatics, systems and synthetic biology to dissect learning and memory processes in the nervous system .


David Arnot, SBS

 

Jean Beggs, SBS

 

  1. The molecular interactions and functions of proteins involved in pre-mRNA splicing in budding yeast.


Garry Blakely, SBS

 

  1. Understanding commensalism and opportunisitic pathogenicity determinants in the anaerobic bacterium Bacteroides fragilis.

  2. Investigating how Type I restriction endonucleases are controlled to ensure bacterial chromosome integrity.

 

Simon Brown, CMVM

  

Dominic Campopiano, SOC

 

  1. Structure/function/mechanism of enzymes and proteins involved in essential biological functions.

  2. Specifically - bacterial cell wall biosynthesis; antibiotic resistance; the mammalian innate immune response; iron transport; natural product biosynthesis; drug detoxification.


David Cavanagh, SBS

 

  1. Development of malaria vaccines based on recombinant surface proteins of the merozoite stage of the P. falciparum.

  2. Study of the development of antibody responses to the malaria parasite in naturally exposed individuals.


Karen Chapman, CMVM

 

  1. Cellular and molecular regulation of glucocorticoid (steroid hormone) action, including ligand access through steroid metabolism.


 Simon Daff, SOC

 

  1. Redox enzyme mechanisms, bioelectrochemistry and biological nitric oxide synthesis.


James Dear, CMVM

 

Peter Doerner, SBS

 

  1. Control of plant growth behaviour by environmental signals, specifically phosphate .

  2. Mechanisms governing proliferation in stem cell and their progeny, specifically the coupling of cell growth and cell division.



Bill Earnshaw, SBS

 

  1. Packaging and segregation of chromosomes.

  2. Discoveries include human-kinetochore proteins, chromosomal passenger proteins and identification of the first natural substrate for caspases in apoptosis.


David Finnegan, SBS

 

  1. Mechanisms of transposition.


Maurice Gallagher, SBS

 

Richard Grainger, SBS

 

  1. The pre-mRNA splicing protein Prp8p and its protein partners.


David Gray, SBS

 

  1. Innate responses of B cells.

  2. Immune regulation by B cells.

  3. Immunological memory.


Paddy Hadoke, CMVM

 

  1. In vitro assessment of vascular function (myography), structure (histology, immunohistochemistry) and angiogenesis (culture).

  2. In vivo models of neointimal proliferation, atherosclerosis and angiogenesis.


Kevin Hardwick, SBS

 

  1. The co-ordination of cell cycle progression with chromosome segregation.


Tony Harmar, CMVM

 

  1. CTCB related interest include the International Union of Basic and Clinical Pharmacology (IUPHAR) database of G protein coupled receptors (GPCRs) and their ligands.


Margarete Heck, SBS

 

 Alison Hulme, SOC

 

  1. Organic Synthesis: Synthesis of natural products which interact with their biological targets through several, or many, chiral groups.

  2. Chemical Biology: Design and synthesis of small molecule probes to investigate the interactions of biomolecules both in vivo and in vitro.


Ted Hupp, CMVM

 

  1. Signal transduction and physiological regulation.

  2. The tumour suppressor p53 pathway.


Henry Jabbour, CMVM

 

Andrew Jarman, CMVM

  

Gary Loake, SBS

 

  1. Regulation of protein function by S-nitrosylation and control of global S-nitrosylation levels during the plant defence response.

  2. Taxol biosynthesis and its regulation.


Poonam Malik, ICB, SBS

 

  1. Regulation of gene expression and posttranslational modifications in mammalian cells.

  2. Nucleo-cytoplasmic transport pathway, protein-mRNA interactions with specific interest in using herpesviruses as a model system.

  3. Effects of nuclear periphery proteins on chromatin organization, modification, cell viability and proliferation.

  4. The structural-Functional relationship and interactome of immediate-early viral regulatory proteins and viral disease pathogenesis with emphasis on translating the molecular-cellular research information into clinical healthcare and medical drug targets.


Keith Matthews, SBS

 

Steven Morley, CMVM

 

  1. Development and maintenance of the adrenal gland, the organ which mediates the body's principal responses to physiological stress (e.g. fear, hunger, injury, disease).

  2. Functions of secretory proteins that lubricate and protect tissue surfaces exposed to the body's external environment (e.g. mouth, lungs, reproductive tract).


John Mullins, CMVM

 

Sari Pennings, CMVM

 

  1. Chromatin dynamics and epigenetics in early development of rodents and zebrafish, nuclear reprogramming, and long range chromatin remodelling in yeast.


Stuart Ralston, CMVM

 

Jim Ross, CMVM

 

  1. Mechanisms of tissue injury and repair, particularly in the liver.

  2. Elucidate the mechanisms controlling stem cell lineage-fate decisions within the developing or injured liver and the micro-environments within which these decisions take place.


Kenneth Sawin, SBS

 

  1. Proteins involved in eukaryotic cell polarity and the microtubule cytoskeleton.


Eric Schirmer, SBS

 

  1. Tissue variation in the nuclear envelope proteome and the complexity of protein interactions within this subnuclear organelle.


Irina Stancheva, SBS

 

 Paul Taylor, SBS

 

  1. Interaction of small molecules with proteins, using crystallography and other biophysical methods.

  2. Large database of small molecules (EDULISS), with 3D structures and a large number of derived descriptors for each capable of compound subset selection and similarity.

  3. Incorporation of the results into the Virtual screening program LIDAEUS, to increase the quality of screening results using the binding site of known protein structures.


David Tollervey, SBS

 

  1. RNA Turnover and Surveillance: Analysis of the quality control systems that monitor the synthesis of all eukaryotic RNAs and RNA-protein complexes.

  2. Ribosome synthesis: Analysis of mechanisms of eukaryotic ribosome synthesis - genetic and systems biology approaches.


Dusan Uhrin, SOC

 

Rob Van't Hof, CMVM

 

Scott Webster, CMVM

 

  1. Research is focused on drug discovery and development of novel drug targets.

  2. Expertise in protein biochemistry, assay development, HTS and medicinal chemistry.


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contacts:

Director:
Prof. Malcolm Walkinshaw
Rm. Swann 3.21
Tel (+44) 0131 6507056
Fax (+44) 0131 6507055
email: malcolm.walkinshaw@ed.ac.uk

Co-Director:
Prof. Paul Barlow
Rm. Swann 3.21
Tel (+44) 0131 6504727
Fax (+44) 0131 6507155
email: Paul.Barlow@ed.ac.uk

Facilities Manager:
Dr. Martin Wear
Rm. Swann 3.20
Tel (+44) 0131 6507054
Fax (+44) 0131 6507055
email: martin.wear@ed.ac.uk

Facilities:

CTCB-Home
Protein Production
Biophysical Characterisation
In Silico Screening
Fermentation
NMR
Cryo-EM
Training

Links:

On-line Booking
Core Column Library

Access Charges/Costs:

Access Charges/Costs
mailto:m.walkinshaw@ed.ac.ukmailto:Paul.Barlow@ed.ac.uk?subject=mailto:m.wear@ed.ac.ukCTCB_-_Home.htmlEPPF_-_Protein_Production.htmlEPPF_-_Biophysical_characterisation.htmlIn_Silico_tools.htmlhttp://www.chem.ed.ac.uk/research/services.htmlhttp://www.bionmr.chem.ed.ac.uk/bionmr/index.htmlhttp://cryo-em.bio.ed.ac.ukTraining.htmlhttp://scibsfs.bch.ed.ac.uk/phpScheduleIt/index.phpCore_Column_Library.htmlAccess_charges_costs.htmlEPPF_-_Protein_Production.htmlshapeimage_3_link_0shapeimage_3_link_1shapeimage_3_link_2shapeimage_3_link_3shapeimage_3_link_4shapeimage_3_link_5shapeimage_3_link_6shapeimage_3_link_7shapeimage_3_link_8shapeimage_3_link_9shapeimage_3_link_10shapeimage_3_link_11shapeimage_3_link_12shapeimage_3_link_13

Location:

University of Edinburgh,

Michael Swann Building, L3

King’s Buildings,

Mayfield Rd.,

EH9 3JR,

UK

Centre for Translational and Chemical Biology - Members